Cargando…

Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades

[Image: see text] By replacing a phenolic ring of (E)-resveratrol with an 1,3,4-oxadiazol-2(3H)-one heterocycle, new resveratrol-based multitarget-directed ligands (MTDLs) were obtained. They were evaluated in several assays related to oxidative stress and inflammation (monoamine oxidases, nuclear e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Herrera-Arozamena, Clara, Estrada-Valencia, Martín, López-Caballero, Patricia, Pérez, Concepción, Morales-García, José A., Pérez-Castillo, Ana, Sastre, Eric del, Fernández-Mendívil, Cristina, Duarte, Pablo, Michalska, Patrycja, Lombardía, José, Senar, Sergio, León, Rafael, López, Manuela G., Rodríguez-Franco, María Isabel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958504/ https://www.ncbi.nlm.nih.gov/pubmed/35245051 http://dx.doi.org/10.1021/acs.jmedchem.1c01883

Ejemplares similares

Multi-Target Directed Ligands (MTDLs) Binding the σ(1) Receptor as Promising Therapeutics: State of the Art and Perspectives
por: Abatematteo, Francesca Serena, et al.
Publicado: (2021)

Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases
por: Herrera-Arozamena, Clara, et al.
Publicado: (2016)

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
por: Estrada-Valencia, Martín, et al.
Publicado: (2019)

Resveratrol: A Focus on Several Neurodegenerative Diseases
por: Tellone, Ester, et al.
Publicado: (2015)

Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches
por: Hussain, Rashad, et al.
Publicado: (2018)

Regenerative Stem Cell Therapy for Neurodegenerative Diseases: An Overview
por: Sivandzade, Farzane, et al.
Publicado: (2021)

The application of resveratrol to mesenchymal stromal cell-based regenerative medicine
por: Hu, Chenxia, et al.
Publicado: (2019)

How does resveratrol influence the genesis of some neurodegenerative diseases?
por: Tellone, Ester, et al.
Publicado: (2016)

Regenerative medicine: could Parkinson's be the first neurodegenerative disease to be cured?
por: Díaz, Mariacruz L
Publicado: (2019)

Promoting the ethical use of safe and effective cell-based products: the Andalusian plan on regenerative medicine
por: Cuende, Natividad, et al.
Publicado: (2020)

Resveratrol: Multi-Targets Mechanism on Neurodegenerative Diseases Based on Network Pharmacology
por: Wang, Wenjun, et al.
Publicado: (2020)

The role of induced pluripotent stem cells in regenerative medicine: neurodegenerative diseases
por: Peng, Jun, et al.
Publicado: (2011)

Editorial: Regenerative medicine in neurodegenerative diseases and aging: challenging the redox homeostasis
por: Mormone, Elisabetta, et al.
Publicado: (2023)

The Regenerative Potential of Substance P
por: Redkiewicz, Patrycja
Publicado: (2022)

Resveratrol and Quercetin Administration Improves Antioxidant DEFENSES and reduces Fatty Liver in Metabolic Syndrome Rats
por: Rubio-Ruiz, Maria Esther, et al.
Publicado: (2019)

Editorial: Mesenchymal Stromal Cell Therapy for Regenerative Medicine
por: Capilla-González, Vivian, et al.
Publicado: (2022)

Toward the Reconstitution of a Two-Enzyme Cascade for Resveratrol Synthesis on Potyvirus Particles
por: Besong-Ndika, Jane, et al.
Publicado: (2016)

Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer’s Disease
por: Michalska, Patrycja, et al.
Publicado: (2020)

Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction
por: Yadav, Ekta, et al.
Publicado: (2022)

Neurotrophic Factors as Regenerative Therapy for Neurodegenerative Diseases: Current Status, Challenges and Future Perspectives
por: El Ouaamari, Yousra, et al.
Publicado: (2023)

Dermic-derived fibroblasts for the study of amyotrophic lateral sclerosis
por: Riancho, Javier, et al.
Publicado: (2020)

Chemoprevention of Experimental Periodontitis in Diabetic Rats with Silk Fibroin Nanoparticles Loaded with Resveratrol
por: Giménez-Siurana, Ana, et al.
Publicado: (2020)

Redox Status and Aging Link in Neurodegenerative Diseases
por: Pérez de la Cruz, Verónica, et al.
Publicado: (2014)

Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases
por: Fukutomi, Ryuuta, et al.
Publicado: (2021)

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine
por: Lopes, Daniela, et al.
Publicado: (2023)

Biological outcome and mapping of total factor cascades in response to HIF induction during regenerative angiogenesis
por: Khatib, Abdel-Majid, et al.
Publicado: (2016)

Redox Status and Aging Link in Neurodegenerative Diseases 2015
por: Pérez de la Cruz, Verónica, et al.
Publicado: (2015)

Enantioselective Synthesis and Pharmacological Evaluation of Aza-CGP37157–Lipoic Acid Hybrids for the Treatment of Alzheimer’s Disease
por: Cores, Ángel, et al.
Publicado: (2022)

Medication-related osteonecrosis of the jaw associated with implant and regenerative treatments: Systematic review
por: Granate-Marques, António, et al.
Publicado: (2019)

Ruthenium-Catalyzed Cascade C—H Functionalization of Phenylacetophenones**
por: Mehta, Vaibhav P, et al.
Publicado: (2014)

Synthesis of Benzofused O- and N-Heterocycles through Cascade Carbopalladation/Cross-Alkylation of Alkynes Involving the C–C Cleavage of Cyclobutanols
por: Pérez-Gómez, Marta, et al.
Publicado: (2022)

Synthesis and Biological Assessment of 4,1-Benzothiazepines with Neuroprotective Activity on the Ca(2+) Overload for the Treatment of Neurodegenerative Diseases and Stroke
por: Viejo, Lucía, et al.
Publicado: (2021)

Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders
por: Valor, Luis M, et al.
Publicado: (2013)

DNA methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells
por: Medina-Aguilar, Rubiceli, et al.
Publicado: (2017)

Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades
por: Subedi, Lalita, et al.
Publicado: (2017)

Lignocellulosic Materials for the Production of Biofuels, Biochemicals and Biomaterials and Applications of Lignocellulose-Based Polyurethanes: A Review
por: Borrero-López, Antonio M., et al.
Publicado: (2022)

Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine
por: Wu, David T., et al.
Publicado: (2021)

Characterization of Resveratrol, Oxyresveratrol, Piceatannol and Roflumilast as Modulators of Phosphodiesterase Activity. Study of Yeast Lifespan
por: Matencio, Adrián, et al.
Publicado: (2020)

Antitumoral Action of Resveratrol Through Adenosinergic Signaling in C6 Glioma Cells
por: Sánchez-Melgar, Alejandro, et al.
Publicado: (2021)

The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs
por: Boto, Alicia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_43tbqk1vgbr8h53ngup3rjso2f