Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms

Targeted delivery of therapeutic proteins toward specific cells and across cell membranes remains major challenges. Here, we develop protein-based delivery systems utilizing detoxified single-chain bacterial toxins such as diphtheria toxin (DT) and botulinum neurotoxin (BoNT)-like toxin, BoNT/X, as...

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Detalles Bibliográficos
Autores principales: Tian, Songhai, Liu, Yang, Appleton, Evan, Wang, Huan, Church, George M., Dong, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958846/
https://www.ncbi.nlm.nih.gov/pubmed/35263584
http://dx.doi.org/10.1016/j.celrep.2022.110476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958846/
https://www.ncbi.nlm.nih.gov/pubmed/35263584
http://dx.doi.org/10.1016/j.celrep.2022.110476

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