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Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms
Targeted delivery of therapeutic proteins toward specific cells and across cell membranes remains major challenges. Here, we develop protein-based delivery systems utilizing detoxified single-chain bacterial toxins such as diphtheria toxin (DT) and botulinum neurotoxin (BoNT)-like toxin, BoNT/X, as...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958846/ https://www.ncbi.nlm.nih.gov/pubmed/35263584 http://dx.doi.org/10.1016/j.celrep.2022.110476 |