A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts, particularly in the MHC, which has population-specific structure. To enable such studies, we constructed a large (n = 21,546) HLA reference panel spanning five global populations based on whole-genome sequenc...

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Detalles Bibliográficos
Autores principales: Luo, Yang, Kanai, Masahiro, Choi, Wanson, Li, Xinyi, Sakaue, Saori, Yamamoto, Kenichi, Ogawa, Kotaro, Gutierrez-Arcelus, Maria, Gregersen, Peter K., Stuart, Philip E., Elder, James T., Forer, Lukas, Schoenherr, Sebastian, Fuchsberger, Christian, Smith, Albert V., Fellay, Jacques, Carrington, Mary, Haas, David W., Guo, Xiuqing, Palmer, Nicholette D., Chen, Yii-Der Ida, Rotter, Jerome I., Taylor, Kent D., Rich, Stephen S., Correa, Adolfo, Wilson, James G., Kathiresan, Sekar, Cho, Michael H., Metspalu, Andres, Esko, Tonu, Okada, Yukinori, Han, Buhm, McLaren, Paul J., Raychaudhuri, Soumya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959399/
https://www.ncbi.nlm.nih.gov/pubmed/34611364
http://dx.doi.org/10.1038/s41588-021-00935-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959399/
https://www.ncbi.nlm.nih.gov/pubmed/34611364
http://dx.doi.org/10.1038/s41588-021-00935-7

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