Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism

Accumulated oncometabolites in the tumor microenvironment (TME) suppresses the metabolism, expansion, and function of T cells. Immunosuppressive TME also impeded Chimeric Antigen Receptor (CAR)-T cells mediated cytotoxicity since CAR-T cells had to adapt the in vivo metabolic characteristics with hi...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Quanjun, Hao, Juan, Chi, Mengyi, Wang, Yaxian, Xin, Bo, Huang, Jinglu, Lu, Jin, Li, Jie, Sun, Xipeng, Li, Chunyan, Huo, Yan, Zhang, Jianping, Han, Yonglong, Guo, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959528/
https://www.ncbi.nlm.nih.gov/pubmed/35355679
http://dx.doi.org/10.1080/2162402X.2022.2055703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959528/
https://www.ncbi.nlm.nih.gov/pubmed/35355679
http://dx.doi.org/10.1080/2162402X.2022.2055703

Ejemplares similares