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Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism

Accumulated oncometabolites in the tumor microenvironment (TME) suppresses the metabolism, expansion, and function of T cells. Immunosuppressive TME also impeded Chimeric Antigen Receptor (CAR)-T cells mediated cytotoxicity since CAR-T cells had to adapt the in vivo metabolic characteristics with hi...

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Detalles Bibliográficos
Autores principales:	Yang, Quanjun, Hao, Juan, Chi, Mengyi, Wang, Yaxian, Xin, Bo, Huang, Jinglu, Lu, Jin, Li, Jie, Sun, Xipeng, Li, Chunyan, Huo, Yan, Zhang, Jianping, Han, Yonglong, Guo, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959528/ https://www.ncbi.nlm.nih.gov/pubmed/35355679 http://dx.doi.org/10.1080/2162402X.2022.2055703

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