Human Mitochondrial DNA Polymerase Metal Dependent UV Lesion Bypassing Ability

Human mitochondrial DNA contains more UV-induced lesions than the nuclear DNA due to lack of mechanism to remove bulky photoproducts. Human DNA polymerase gamma (Pol γ) is the sole DNA replicase in mitochondria, which contains a polymerase (pol) and an exonuclease (exo) active site. Previous studies...

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Detalles Bibliográficos
Autores principales: Park, Joon, Baruch-Torres, Noe, Iwai, Shigenori, Herrmann, Geoffrey K., Brieba, Luis G., Yin, Y. Whitney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959595/
https://www.ncbi.nlm.nih.gov/pubmed/35355510
http://dx.doi.org/10.3389/fmolb.2022.808036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959595/
https://www.ncbi.nlm.nih.gov/pubmed/35355510
http://dx.doi.org/10.3389/fmolb.2022.808036

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