P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis

Neurofibromatosis type 1 (NF1) is characterized by nerve tumors called neurofibromas, in which Schwann cells (SCs) show deregulated RAS signaling. NF1 is also implicated in regulation of cAMP. We identified the G-protein-coupled receptor (GPCR) P2ry14 in human neurofibromas, neurofibroma-derived SC...

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Detalles Bibliográficos
Autores principales: Patritti Cram, Jennifer, Wu, Jianqiang, Coover, Robert A, Rizvi, Tilat A, Chaney, Katherine E, Ravindran, Ramya, Cancelas, Jose A, Spinner, Robert J, Ratner, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959601/
https://www.ncbi.nlm.nih.gov/pubmed/35311647
http://dx.doi.org/10.7554/eLife.73511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959601/
https://www.ncbi.nlm.nih.gov/pubmed/35311647
http://dx.doi.org/10.7554/eLife.73511

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