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Targeting Integrins for Cancer Therapy - Disappointments and Opportunities

Integrins mediate adhesive interactions between cells and their environment, including neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane receptors bind extracellular ligands with their globular head domains and connect to the cytoskeleton through multi-protein inter...

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Detalles Bibliográficos
Autores principales: Bergonzini, Cecilia, Kroese, Kim, Zweemer, Annelien J. M., Danen, Erik H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959606/
https://www.ncbi.nlm.nih.gov/pubmed/35356286
http://dx.doi.org/10.3389/fcell.2022.863850