Cargando…

Population balance modelling captures host cell protein dynamics in CHO cell cultures

Monoclonal antibodies (mAbs) have been extensively studied for their wide therapeutic and research applications. Increases in mAb titre has been achieved mainly by cell culture media/feed improvement and cell line engineering to increase cell density and specific mAb productivity. However, this impr...

Descripción completa

Detalles Bibliográficos
Autores principales: Alhuthali, Sakhr, Kontoravdi, Cleo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959726/
https://www.ncbi.nlm.nih.gov/pubmed/35320326
http://dx.doi.org/10.1371/journal.pone.0265886