The Programmed Death-1 Pathway Counter-Regulates Inflammation-Induced Osteoclast Activity in Clinical and Experimental Settings

OBJECTIVE: The programmed death-1 (PD-1) pathway is essential for maintaining self-tolerance and plays an important role in autoimmunity, including rheumatoid arthritis (RA). Here, we investigated how membrane-bound and soluble (s)PD-1 influence bone homeostasis during chronic inflammation, exemplif...

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Detalles Bibliográficos
Autores principales: Greisen, Stinne R., Kragstrup, Tue W., Thomsen, Jesper Skovhus, Hørslev-Pedersen, Kim, Hetland, Merete Lund, Stengaard-Pedersen, Kristian, Østergaard, Mikkel, Ørnbjerg, Lykke, Junker, Peter, Sharpe, Arlene H., Freeman, Gordon J., Hvid, Malene, Moestrup, Søren K., Hauge, Ellen Margrethe, Deleuran, Bent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959817/
https://www.ncbi.nlm.nih.gov/pubmed/35356000
http://dx.doi.org/10.3389/fimmu.2022.773946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959817/
https://www.ncbi.nlm.nih.gov/pubmed/35356000
http://dx.doi.org/10.3389/fimmu.2022.773946

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