Translocator Protein (TSPO) Alleviates Neuropathic Pain by Activating Spinal Autophagy and Nuclear SIRT1/PGC-1α Signaling in a Rat L5 SNL Model

PURPOSE: Recent studies showed promotion of astrocyte autophagy in the spinal cord would provide analgesic effects. Silent information regulator T1 (SIRT1) and α subunit of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1α) are two master regulators of endogenous antioxidant defense...

Descripción completa

Detalles Bibliográficos
Autores principales: Hao, Can, Ma, Bingjie, Gao, Nan, Jin, Tian, Liu, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959876/
https://www.ncbi.nlm.nih.gov/pubmed/35356265
http://dx.doi.org/10.2147/JPR.S359397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959876/
https://www.ncbi.nlm.nih.gov/pubmed/35356265
http://dx.doi.org/10.2147/JPR.S359397

Ejemplares similares