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Translocator Protein (TSPO) Alleviates Neuropathic Pain by Activating Spinal Autophagy and Nuclear SIRT1/PGC-1α Signaling in a Rat L5 SNL Model

PURPOSE: Recent studies showed promotion of astrocyte autophagy in the spinal cord would provide analgesic effects. Silent information regulator T1 (SIRT1) and α subunit of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1α) are two master regulators of endogenous antioxidant defense...

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Detalles Bibliográficos
Autores principales:	Hao, Can, Ma, Bingjie, Gao, Nan, Jin, Tian, Liu, Xiaoming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959876/ https://www.ncbi.nlm.nih.gov/pubmed/35356265 http://dx.doi.org/10.2147/JPR.S359397

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