Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis

Irisin, a myokine secreted by muscle during physical exercise, is known to have biological activities in different cell types. Chondrocyte inflammation and pyroptosis have been shown to play important roles in osteoarthritis (OA). In this study, we investigated the effects of exercise-induced irisin...

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Detalles Bibliográficos
Autores principales: Jia, Shuangshuo, Yang, Yue, Bai, Yishu, Wei, Yingliang, Zhang, He, Tian, Yicheng, Liu, Jiabao, Bai, Lunhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959944/
https://www.ncbi.nlm.nih.gov/pubmed/35356271
http://dx.doi.org/10.3389/fcell.2022.797855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959944/
https://www.ncbi.nlm.nih.gov/pubmed/35356271
http://dx.doi.org/10.3389/fcell.2022.797855

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