35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope

The SARS-CoV-2 Omicron variant harbors more than 30 mutations in the spike protein, leading to immune evasion from many therapeutic neutralizing antibodies. We reveal that a receptor-binding domain (RBD)-targeting monoclonal antibody, 35B5, exhibits potent neutralizing efficacy to Omicron. Cryo-elec...

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Detalles Bibliográficos
Autores principales: Wang, Xiaofei, Chen, Xiangyu, Tan, Jiaxing, Yue, Shuai, Zhou, Runhong, Xu, Yan, Lin, Yao, Yang, Yang, Zhou, Yan, Deng, Kai, Chen, Zhiwei, Ye, Lilin, Zhu, Yongqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960183/
https://www.ncbi.nlm.nih.gov/pubmed/35436443
http://dx.doi.org/10.1016/j.chom.2022.03.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960183/
https://www.ncbi.nlm.nih.gov/pubmed/35436443
http://dx.doi.org/10.1016/j.chom.2022.03.035

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