Cargando…

35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope

The SARS-CoV-2 Omicron variant harbors more than 30 mutations in the spike protein, leading to immune evasion from many therapeutic neutralizing antibodies. We reveal that a receptor-binding domain (RBD)-targeting monoclonal antibody, 35B5, exhibits potent neutralizing efficacy to Omicron. Cryo-elec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xiaofei, Chen, Xiangyu, Tan, Jiaxing, Yue, Shuai, Zhou, Runhong, Xu, Yan, Lin, Yao, Yang, Yang, Zhou, Yan, Deng, Kai, Chen, Zhiwei, Ye, Lilin, Zhu, Yongqun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2022
Materias:	Short Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960183/ https://www.ncbi.nlm.nih.gov/pubmed/35436443 http://dx.doi.org/10.1016/j.chom.2022.03.035

Ejemplares similares

A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern
por: Yuan, Mengqi, et al.
Publicado: (2022)

Polyvalent Nano-Lectin Potently Neutralizes SARS-CoV-2 by Targeting Glycans on the Viral Spike Protein
por: Budhadev, Darshita, et al.
Publicado: (2023)

Structures of Omicron spike complexes and implications for neutralizing antibody development
por: Guo, Hangtian, et al.
Publicado: (2022)

Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants
por: Lin, Wei-Shuo, et al.
Publicado: (2021)

A spike protein S2 antibody efficiently neutralizes the Omicron variant
por: Hu, Jia, et al.
Publicado: (2022)

Human neutralizing antibodies for SARS-CoV-2 prevention and immunotherapy
por: Zhou, Dongyan, et al.
Publicado: (2021)

Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein
por: Zhong, Lilin, et al.
Publicado: (2009)

A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants
por: Modhiran, Naphak, et al.
Publicado: (2023)

Ensemble-based, glycan-dependent epitope analysis of SARS-CoV-2 spike protein
por: Chen, Tianle, et al.
Publicado: (2022)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

Effects of N-glycan modifications on spike expression, virus infectivity, and neutralization sensitivity in ancestral compared to Omicron SARS-CoV-2 variants
por: Lusvarghi, Sabrina, et al.
Publicado: (2023)

A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
por: Wang, Xiaofei, et al.
Publicado: (2022)

Nanograms of SARS-CoV-2 spike protein delivered by exosomes induce potent neutralization of both delta and omicron variants
por: Cacciottolo, Mafalda, et al.
Publicado: (2023)

Rational Design of SARS-CoV-2 Spike Glycoproteins To Increase Immunogenicity By T Cell Epitope Engineering
por: Ong, Edison, et al.
Publicado: (2020)

Computational design of SARS-CoV-2 spike glycoproteins to increase immunogenicity by T cell epitope engineering
por: Ong, Edison, et al.
Publicado: (2020)

Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy
por: Walls, Alexandra C, et al.
Publicado: (2016)

A New Neutralization Epitope in the Spike Protein of Porcine Epidemic Diarrhea Virus
por: Liu, Jianbo, et al.
Publicado: (2022)

Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies
por: Julien, J, et al.
Publicado: (2012)

Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit
por: Hurlburt, Nicholas K., et al.
Publicado: (2022)

Effects of SARS-CoV-2 Omicron BA.1 Spike Mutations on T-Cell Epitopes in Mice
por: Wang, Yudong, et al.
Publicado: (2023)

SARS-CoV-2 spike protein S1 subunit induces potent neutralizing responses in mice and is effective against Delta and Omicron variants
por: Mamedov, Tarlan, et al.
Publicado: (2023)

Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection
por: Guo, Yu, et al.
Publicado: (2023)

Neutralization Epitopes in Trimer and Pentamer Complexes Recognized by Potent Cytomegalovirus-Neutralizing Human Monoclonal Antibodies
por: Ai, Yuanbao, et al.
Publicado: (2022)

A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery
por: Zhang, Xinghai, et al.
Publicado: (2022)

Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence
por: Hastie, Kathryn M., et al.
Publicado: (2023)

Impact of glycan cloud on the B-cell epitope prediction of SARS-CoV-2 Spike protein
por: Wintjens, René, et al.
Publicado: (2020)

Identification and characterization of a neutralizing-epitope-containing spike protein fragment in turkey coronavirus
por: Chen, Yi-Ning, et al.
Publicado: (2011)

Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
por: Bowen, John E., et al.
Publicado: (2022)

Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein
por: Zhou, Haixia, et al.
Publicado: (2019)

Concerted hinge motions in SARS-CoV-2 spike modulated by glycan-glycan and glycan-lipid interactions
por: Kapoor, Karan, et al.
Publicado: (2022)

Potent Neutralization of SARS-CoV-2 by Hetero-Bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain
por: Ma, Huan, et al.
Publicado: (2021)

Neutralizing antibodies against EBV gp42 show potent in vivo protection and define novel epitopes
por: Wu, Qian, et al.
Publicado: (2023)

Computational design of N‐linked glycans for high throughput epitope profiling
por: Greisen, Per Jr., et al.
Publicado: (2023)

SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope
por: He, Ping, et al.
Publicado: (2022)

Omicron-included mutation-induced changes in epitopes of SARS-CoV-2 spike protein and effectiveness assessments of current antibodies
por: Guo, Du, et al.
Publicado: (2022)

Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants
por: Chen, Zhaochun, et al.
Publicado: (2022)

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients
por: Li, Yang, et al.
Publicado: (2020)

A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge
por: Zhou, Biao, et al.
Publicado: (2022)

Nasal Spray of Neutralizing Monoclonal Antibody 35B5 Confers Potential Prophylaxis Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Small-Scale Clinical Trial
por: Lin, Yao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n3tv8ektsjf6dp519603qscd0p