Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells

Short persistence and early exhaustion of T cells are major limits to the efficacy and broad application of immunotherapy. Exhausted T and chimeric antigen receptor (CAR)-T cells upregulate expression of genes associated with terminated T cell differentiation, aerobic glycolysis and apoptosis. Among...

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Detalles Bibliográficos
Autores principales: Huang, Yue, Si, Xiaohui, Shao, Mi, Teng, Xinyi, Xiao, Gang, Huang, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960222/
https://www.ncbi.nlm.nih.gov/pubmed/35346311
http://dx.doi.org/10.1186/s13045-022-01255-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960222/
https://www.ncbi.nlm.nih.gov/pubmed/35346311
http://dx.doi.org/10.1186/s13045-022-01255-x

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