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Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells

Short persistence and early exhaustion of T cells are major limits to the efficacy and broad application of immunotherapy. Exhausted T and chimeric antigen receptor (CAR)-T cells upregulate expression of genes associated with terminated T cell differentiation, aerobic glycolysis and apoptosis. Among...

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Detalles Bibliográficos
Autores principales:	Huang, Yue, Si, Xiaohui, Shao, Mi, Teng, Xinyi, Xiao, Gang, Huang, He
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960222/ https://www.ncbi.nlm.nih.gov/pubmed/35346311 http://dx.doi.org/10.1186/s13045-022-01255-x

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