Chemical Biology Screening Identifies a Vulnerability to Checkpoint Kinase Inhibitors in TSC2-Deficient Renal Angiomyolipomas

The tuberous sclerosis complex (TSC) is a rare genetic syndrome and multisystem disease resulting in tumor formation in major organs. A molecular hallmark of TSC is a dysregulation of the mammalian target of rapamycin (mTOR) through loss-of-function mutations in either tumor suppressor TSC1 or TSC2....

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Detalles Bibliográficos
Autores principales: Vaughan, Robert M., Kordich, Jennifer J., Chan, Chun-Yuan, Sasi, Nanda K., Celano, Stephanie L., Sisson, Kellie A., Van Baren, Megan, Kortus, Matthew G., Aguiar, Dean J., Martin, Katie R., MacKeigan, Jeffrey P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960247/
https://www.ncbi.nlm.nih.gov/pubmed/35359406
http://dx.doi.org/10.3389/fonc.2022.852859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960247/
https://www.ncbi.nlm.nih.gov/pubmed/35359406
http://dx.doi.org/10.3389/fonc.2022.852859

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