Phenotypic characterization of Cdkl5-knockdown neurons establishes elongated cilia as a functional assay for CDKL5 Deficiency Disorder

CDKL5 Deficiency Disorder (CDD) is a severe encephalopathy characterized by intractable epilepsy, infantile spasms, and cognitive disabilities. The detrimental CNS manifestations and lack of therapeutic interventions represent unmet needs, necessitating identification of CDD-dependent phenotypes for...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Nardo, Alessia, Rühmkorf, Alina, Award, Patricia, Brennecke, Ashton, Fagiolini, Michela, Sahin, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960319/
https://www.ncbi.nlm.nih.gov/pubmed/34624412
http://dx.doi.org/10.1016/j.neures.2021.10.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960319/
https://www.ncbi.nlm.nih.gov/pubmed/34624412
http://dx.doi.org/10.1016/j.neures.2021.10.001

Ejemplares similares