An anti-PD-1–GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy

Costimulatory receptors such as glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) play key roles in regulating the effector functions of T cells. In human clinical trials, however, GITR agonist antibodies have shown limited therapeutic effect, which may be due to suboptima...

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Detalles Bibliográficos
Autores principales: Chan, Sarah, Belmar, Nicole, Ho, Sun, Rogers, Bryan, Stickler, Marcia, Graham, Michelle, Lee, Eileen, Tran, Ninian, Zhang, Dong, Gupta, Priyanka, Sho, Mien, MacDonough, Tracy, Woolley, Andrew, Kim, Han, Zhang, Hong, Liu, Wei, Zheng, Pingping, Dezso, Zoltan, Halliwill, Kyle, Ceccarelli, Michele, Rhodes, Susan, Thakur, Archana, Forsyth, Charles M., Xiong, Mengli, Tan, Siu Sze, Iyer, Ramesh, Lake, Marc, Digiammarino, Enrico, Zhou, Li, Bigelow, Lance, Longenecker, Kenton, Judge, Russell A., Liu, Cassie, Trumble, Max, Remis, Jonathan P., Fox, Melvin, Cairns, Belinda, Akamatsu, Yoshiko, Hollenbaugh, Diane, Harding, Fiona, Alvarez, Hamsell M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960412/
https://www.ncbi.nlm.nih.gov/pubmed/35256819
http://dx.doi.org/10.1038/s43018-022-00334-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960412/
https://www.ncbi.nlm.nih.gov/pubmed/35256819
http://dx.doi.org/10.1038/s43018-022-00334-9

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