Selective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages

RNase2 is the member of the RNaseA family most abundant in macrophages. Here, we knocked out RNase2 in THP-1 cells and analysed the response to Respiratory Syncytial Virus (RSV). RSV induced RNase2 expression, which significantly enhanced cell survival. Next, by cP-RNAseq sequencing, which amplifies...

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Detalles Bibliográficos
Autores principales: Lu, Lu, Li, Jiarui, Wei, Ranlei, Guidi, Irene, Cozzuto, Luca, Ponomarenko, Julia, Prats-Ejarque, Guillem, Boix, Ester
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960563/
https://www.ncbi.nlm.nih.gov/pubmed/35347428
http://dx.doi.org/10.1007/s00018-022-04229-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960563/
https://www.ncbi.nlm.nih.gov/pubmed/35347428
http://dx.doi.org/10.1007/s00018-022-04229-x

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