Elucidating a Complicated Enantioselective Metabolic Profile: A Study From Rats to Humans Using Optically Pure Doxazosin

Doxazosin (DOX) is prescribed as a racemic drug for the clinical treatment of benign prostatic hyperplasia and hypertension. Recent studies found that the two enantiomers of DOX exhibit differences in blood concentration and pharmacological effects. However, the stereoselective metabolic characteris...

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Detalles Bibliográficos
Autores principales: Kong, Dezhi, Tian, Yuan, Duan, Kunfeng, Guo, Wenyan, Zhang, Qingning, Zhang, Panpan, Yang, Zuxiao, Qin, Xia, Ren, Leiming, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960639/
https://www.ncbi.nlm.nih.gov/pubmed/35359849
http://dx.doi.org/10.3389/fphar.2022.834897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960639/
https://www.ncbi.nlm.nih.gov/pubmed/35359849
http://dx.doi.org/10.3389/fphar.2022.834897

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