Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice

AIMS/HYPOTHESIS: Diabetic cardiomyopathy (DCM) is a serious and under-recognised complication of diabetes. The first sign is diastolic dysfunction, which progresses to heart failure. The pathophysiology of DCM is incompletely understood but microcirculatory changes are important. Endothelial glycoca...

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Detalles Bibliográficos
Autores principales: Qiu, Yan, Buffonge, Stanley, Ramnath, Raina, Jenner, Sophie, Fawaz, Sarah, Arkill, Kenton P., Neal, Chris, Verkade, Paul, White, Stephen J., Hezzell, Melanie, Salmon, Andrew H. J., Suleiman, M.-Saadeh, Welsh, Gavin I., Foster, Rebecca R., Madeddu, Paolo, Satchell, Simon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960650/
https://www.ncbi.nlm.nih.gov/pubmed/35211778
http://dx.doi.org/10.1007/s00125-022-05650-4

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