Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations

The protein α-synuclein, a key player in Parkinson’s disease (PD) and other synucleinopathies, exists in different physiological conformations: cytosolic unfolded aggregation-prone monomers and helical aggregation-resistant multimers. It has been shown that familial PD-associated missense mutations...

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Detalles Bibliográficos
Autores principales: de Boni, Laura, Watson, Aurelia Hays, Zaccagnini, Ludovica, Wallis, Amber, Zhelcheska, Kristina, Kim, Nora, Sanderson, John, Jiang, Haiyang, Martin, Elodie, Cantlon, Adam, Rovere, Matteo, Liu, Lei, Sylvester, Marc, Lashley, Tammaryn, Dettmer, Ulf, Jaunmuktane, Zane, Bartels, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960659/
https://www.ncbi.nlm.nih.gov/pubmed/35141810
http://dx.doi.org/10.1007/s00401-022-02406-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960659/
https://www.ncbi.nlm.nih.gov/pubmed/35141810
http://dx.doi.org/10.1007/s00401-022-02406-7

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