Hyperphosphorylated Human Tau Accumulates at the Synapse, Localizing on Synaptic Mitochondrial Outer Membranes and Disrupting Respiration in a Mouse Model of Tauopathy

Neurogenerative disorders, such as Alzheimer’s disease (AD), represent a growing public health challenge in aging societies. Tauopathies, a subset of neurodegenerative disorders that includes AD, are characterized by accumulation of fibrillar and hyperphosphorylated forms of microtubule-associated p...

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Detalles Bibliográficos
Autores principales: Trease, Andrew J., George, Joseph W., Roland, Nashanthea J., Lichter, Eliezer Z., Emanuel, Katy, Totusek, Steven, Fox, Howard S., Stauch, Kelly L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960727/
https://www.ncbi.nlm.nih.gov/pubmed/35359570
http://dx.doi.org/10.3389/fnmol.2022.852368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960727/
https://www.ncbi.nlm.nih.gov/pubmed/35359570
http://dx.doi.org/10.3389/fnmol.2022.852368

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