Cargando…

Hyperphosphorylated Human Tau Accumulates at the Synapse, Localizing on Synaptic Mitochondrial Outer Membranes and Disrupting Respiration in a Mouse Model of Tauopathy

Neurogenerative disorders, such as Alzheimer’s disease (AD), represent a growing public health challenge in aging societies. Tauopathies, a subset of neurodegenerative disorders that includes AD, are characterized by accumulation of fibrillar and hyperphosphorylated forms of microtubule-associated p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Trease, Andrew J., George, Joseph W., Roland, Nashanthea J., Lichter, Eliezer Z., Emanuel, Katy, Totusek, Steven, Fox, Howard S., Stauch, Kelly L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960727/ https://www.ncbi.nlm.nih.gov/pubmed/35359570 http://dx.doi.org/10.3389/fnmol.2022.852368

Ejemplares similares

Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?
por: Alavi Naini, Seyedeh Maryam, et al.
Publicado: (2015)

SHORT TELOMERES ASSOCIATE WITH HYPERPHOSPHORYLATED TAU BURDEN IN PRIMARY AGE-RELATED TAUOPATHY
por: McMillan, Corey, et al.
Publicado: (2022)

Longitudinal in vivo metabolic labeling reveals tissue-specific mitochondrial proteome turnover rates and proteins selectively altered by parkin deficiency
por: Stauch, K. L., et al.
Publicado: (2023)

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
por: Šimić, Goran, et al.
Publicado: (2016)

Distribution of tau hyperphosphorylation in canine dementia resembles early Alzheimer’s disease and other tauopathies
por: Abey, Ajantha, et al.
Publicado: (2020)

Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization
por: Yadikar, Hamad, et al.
Publicado: (2020)

Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Drosophila Model of Tauopathy and Neuroblastoma Cells
por: Chatterjee, Shreyasi, et al.
Publicado: (2019)

Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation
por: Barron, Matthew R., et al.
Publicado: (2020)

Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy
por: Alavi Naini, Seyedeh Maryam, et al.
Publicado: (2018)

Correction to: Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy
por: Naini, Seyedeh Maryam Alavi, et al.
Publicado: (2020)

Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models
por: Selvarasu, Karthikeyan, et al.
Publicado: (2022)

Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction
por: Zhang, Xingyu, et al.
Publicado: (2021)

Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases
por: Duka, Valeriy, et al.
Publicado: (2013)

Hyperphosphorylation-Induced Tau Oligomers
por: Iqbal, Khalid, et al.
Publicado: (2013)

Truncated tau deregulates synaptic markers in rat model for human tauopathy
por: Jadhav, Santosh, et al.
Publicado: (2015)

Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging
por: Yuan, Minghao, et al.
Publicado: (2022)

Parkinson's disease relevant pathological features are manifested in male Pink1/Parkin deficient rats
por: Lamberty, Benjamin G., et al.
Publicado: (2023)

Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer’s Disease and Related Tauopathies
por: Castillo-Carranza, Diana L, et al.
Publicado: (2017)

Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy
por: Morris, Meaghan, et al.
Publicado: (2023)

Activated gliosis, accumulation of amyloid β, and hyperphosphorylation of tau in aging canines with and without cognitive decline
por: Hines, Amelia D., et al.
Publicado: (2023)

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau
por: Melov, Simon, et al.
Publicado: (2007)

Hyperphosphorylated tau in young and middle-aged subjects
por: Elobeid, Adila, et al.
Publicado: (2011)

PINCH in the Cellular Stress Response to Tau-Hyperphosphorylation
por: Ozdemir, Ahmet Yunus, et al.
Publicado: (2013)

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
por: Tepper, Katharina, et al.
Publicado: (2014)

Immunological memory to hyperphosphorylated tau in asymptomatic individuals
por: Pascual, Gabriel, et al.
Publicado: (2017)

Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model
por: Lauretti, E, et al.
Publicado: (2017)

Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in Tauopathy
por: Tao, Xianzun, et al.
Publicado: (2023)

Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer’s Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated
por: Barthélemy, Nicolas R., et al.
Publicado: (2022)

Transcellular Spreading of Tau in Tauopathies
por: Demaegd, Koen, et al.
Publicado: (2018)

Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg4510 Model of Tauopathy
por: Kopeikina, Katherine J., et al.
Publicado: (2013)

Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation
por: Huang, Yunpeng, et al.
Publicado: (2014)

GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions
por: Zhu, Huazhang, et al.
Publicado: (2018)

Altered Synapse Stability in the Early Stages of Tauopathy
por: Jackson, Johanna S., et al.
Publicado: (2017)

AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy
por: Ising, Christina, et al.
Publicado: (2017)

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion
por: Plouffe, Vanessa, et al.
Publicado: (2012)

Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset
por: Rodriguez-Callejas, Juan D., et al.
Publicado: (2016)

Are Tau Aggregates Toxic or Protective in Tauopathies?
por: Cowan, Catherine M., et al.
Publicado: (2013)

NMR Studies of Tau Protein in Tauopathies
por: Kitoka, Kristine, et al.
Publicado: (2021)

Accumulation of Vesicle-Associated Human Tau in Distal Dendrites Drives Degeneration and Tau Secretion in an In Situ Cellular Tauopathy Model
por: Lee, Sangmook, et al.
Publicado: (2012)

Correction: AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy
por: Ising, Christina, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_lcu86c7nvtr7nhlcff6grsqtmd