Effect of LRRK2 protein and activity on stimulated cytokines in human monocytes and macrophages

Leucine-rich-repeat kinase 2 (LRRK2), a potential therapeutic target for the treatment of Parkinson’s disease (PD), is highly expressed in monocytes and macrophages and may play a role in the regulation of inflammatory pathways. To determine how LRRK2 protein levels and/or its activity modulate infl...

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Detalles Bibliográficos
Autores principales: Ahmadi Rastegar, Diba, Hughes, Laura P., Perera, Gayathri, Keshiya, Shikara, Zhong, Siying, Gao, Jianqun, Halliday, Glenda M., Schüle, Birgitt, Dzamko, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960803/
https://www.ncbi.nlm.nih.gov/pubmed/35347144
http://dx.doi.org/10.1038/s41531-022-00297-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960803/
https://www.ncbi.nlm.nih.gov/pubmed/35347144
http://dx.doi.org/10.1038/s41531-022-00297-9

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