Cargando…

Effect of LRRK2 protein and activity on stimulated cytokines in human monocytes and macrophages

Leucine-rich-repeat kinase 2 (LRRK2), a potential therapeutic target for the treatment of Parkinson’s disease (PD), is highly expressed in monocytes and macrophages and may play a role in the regulation of inflammatory pathways. To determine how LRRK2 protein levels and/or its activity modulate infl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahmadi Rastegar, Diba, Hughes, Laura P., Perera, Gayathri, Keshiya, Shikara, Zhong, Siying, Gao, Jianqun, Halliday, Glenda M., Schüle, Birgitt, Dzamko, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960803/ https://www.ncbi.nlm.nih.gov/pubmed/35347144 http://dx.doi.org/10.1038/s41531-022-00297-9

Ejemplares similares

Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations
por: Labrador-Garrido, Adahir, et al.
Publicado: (2023)

Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice
por: Zhao, Ye, et al.
Publicado: (2018)

Parkinson’s progression prediction using machine learning and serum cytokines
por: Ahmadi Rastegar, Diba, et al.
Publicado: (2019)

A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology
por: Chedid, Jessica, et al.
Publicado: (2022)

Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers
por: Zhao, Ye, et al.
Publicado: (2018)

Leucine Rich Repeat Kinase 2 and Innate Immunity
por: Ahmadi Rastegar, Diba, et al.
Publicado: (2020)

Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology
por: Dzamko, Nicolas, et al.
Publicado: (2016)

Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism
por: Chittoor-Vinod, Vinita G., et al.
Publicado: (2021)

Inhibitor treatment of peripheral mononuclear cells from Parkinson’s disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker
por: Perera, G., et al.
Publicado: (2016)

Reduced glucocerebrosidase activity in monocytes from patients with Parkinson’s disease
por: Atashrazm, Farzaneh, et al.
Publicado: (2018)

LRRK2 and Lipid Pathways: Implications for Parkinson’s Disease
por: Galper, Jasmin, et al.
Publicado: (2022)

LRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectives
por: Atashrazm, Farzaneh, et al.
Publicado: (2016)

Glucocerebrosidase Activity is Reduced in Cryopreserved Parkinson’s Disease Patient Monocytes and Inversely Correlates with Motor Severity
por: Hughes, Laura P., et al.
Publicado: (2021)

Single-cell DNA methylation sequencing by combinatorial indexing and enzymatic DNA methylation conversion
por: Chatterton, Zac, et al.
Publicado: (2023)

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain
por: Dhekne, Herschel S, et al.
Publicado: (2018)

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons
por: Bieri, Gregor, et al.
Publicado: (2019)

LRRK2 contributes to monocyte dysregulation in Parkinson’s disease
por: Bliederhaeuser, Corinna, et al.
Publicado: (2016)

Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis
por: Dzamko, Nicolas, et al.
Publicado: (2014)

Polarized monocyte response to cytokine stimulation
por: Nagorsen, Dirk, et al.
Publicado: (2005)

The cytokine language of monocytes and macrophages in systemic sclerosis
por: Christmann, Romy B, et al.
Publicado: (2010)

LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models
por: Guerreiro, Patrícia Silva, et al.
Publicado: (2012)

Cytokine activity in Parkinson’s disease
por: Dzamko, Nicolas
Publicado: (2023)

Inflammatory profile in LRRK2-associated prodromal and clinical PD
por: Brockmann, Kathrin, et al.
Publicado: (2016)

Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons
por: Cobos Jiménez, Viviana, et al.
Publicado: (2012)

Evaluation of plasma levels of NFL, GFAP, UCHL1 and tau as Parkinson's disease biomarkers using multiplexed single molecule counting
por: Youssef, Priscilla, et al.
Publicado: (2023)

Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2
por: Deng, Xianming, et al.
Publicado: (2011)

Comparison of Different Platform Immunoassays for the Measurement of Plasma Alpha-Synuclein in Parkinson’s Disease Patients
por: Youssef, Priscilla, et al.
Publicado: (2021)

Inhibition of LRRK2 kinase activity stimulates macroautophagy()
por: Manzoni, Claudia, et al.
Publicado: (2013)

LRRK2 activation controls the repair of damaged endomembranes in macrophages
por: Herbst, Susanne, et al.
Publicado: (2020)

Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages
por: Oun, Asmaa, et al.
Publicado: (2023)

Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation
por: Thévenet, Jonathan, et al.
Publicado: (2011)

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain
por: Xu, Enquan, et al.
Publicado: (2022)

Cytokine response to lipoprotein lipid loading in human monocyte-derived macrophages
por: Persson, Jenny, et al.
Publicado: (2006)

Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice
por: Giesert, Florian, et al.
Publicado: (2013)

Optimization of stimulation and staining conditions for intracellular cytokine staining (ICS) for determination of cytokine-producing T cells and monocytes
por: Mandala, Wilson, et al.
Publicado: (2021)

Dynamic and redundant regulation of LRRK2 and LRRK1 expression
por: Biskup, Saskia, et al.
Publicado: (2007)

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
por: Malik, Asad U., et al.
Publicado: (2021)

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization
por: Dzamko, Nicolas, et al.
Publicado: (2010)

Recombinant Cpn 0810 stimulates proinflammatory cytokine expression and apoptosis in human monocytes
por: CHEN, YUYU, et al.
Publicado: (2015)

Sarcoidosis exosomes stimulate monocytes to produce pro-inflammatory cytokines and CCL2
por: Wahlund, Casper J. E., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r3rlo1m3floq3lh1heh23rvcrs