Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1

Burkholderia pseudomallei lethal factor 1 (BLF1) exhibits site-specific glutamine deamidase activity against the eukaryotic RNA helicase, eIF4A, thereby blocking mammalian protein synthesis. The structure of a complex between BLF1 C94S and human eIF4A shows that the toxin binds in the cleft between...

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Detalles Bibliográficos
Autores principales: Mobbs, George W., Aziz, Adli A., Dix, Samuel R., Blackburn, G. M., Sedelnikova, Sveta E., Minshull, Thomas C., Dickman, Mark J., Baker, Patrick J., Nathan, Sheila, Raih, Mohd Firdaus, Rice, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960835/
https://www.ncbi.nlm.nih.gov/pubmed/35347220
http://dx.doi.org/10.1038/s42003-022-03186-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960835/
https://www.ncbi.nlm.nih.gov/pubmed/35347220
http://dx.doi.org/10.1038/s42003-022-03186-2

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