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Non-canonical ubiquitylation makes its mark on Rap2 and cell motility
Ubiquitin modification controls protein stability and cargo trafficking, and in this issue Duncan et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202107114) reveal a unique mechanism through which Rab40b/Cul5-mediated ubiquitylation of Rap2 regulates its activity and recycling to the leading...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961291/ https://www.ncbi.nlm.nih.gov/pubmed/35333280 http://dx.doi.org/10.1083/jcb.202203029 |
| _version_ | 1784677565677436928 |
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| author | Caswell, Patrick T. |
| author_facet | Caswell, Patrick T. |
| author_sort | Caswell, Patrick T. |
| collection | PubMed |
| description | Ubiquitin modification controls protein stability and cargo trafficking, and in this issue Duncan et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202107114) reveal a unique mechanism through which Rab40b/Cul5-mediated ubiquitylation of Rap2 regulates its activity and recycling to the leading edge to control cell migration and invasion. |
| format | Online Article Text |
| id | pubmed-8961291 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-89612912022-10-04 Non-canonical ubiquitylation makes its mark on Rap2 and cell motility Caswell, Patrick T. J Cell Biol Spotlight Ubiquitin modification controls protein stability and cargo trafficking, and in this issue Duncan et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202107114) reveal a unique mechanism through which Rab40b/Cul5-mediated ubiquitylation of Rap2 regulates its activity and recycling to the leading edge to control cell migration and invasion. Rockefeller University Press 2022-03-25 /pmc/articles/PMC8961291/ /pubmed/35333280 http://dx.doi.org/10.1083/jcb.202203029 Text en © 2022 Caswell https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | Spotlight Caswell, Patrick T. Non-canonical ubiquitylation makes its mark on Rap2 and cell motility |
| title | Non-canonical ubiquitylation makes its mark on Rap2 and cell motility |
| title_full | Non-canonical ubiquitylation makes its mark on Rap2 and cell motility |
| title_fullStr | Non-canonical ubiquitylation makes its mark on Rap2 and cell motility |
| title_full_unstemmed | Non-canonical ubiquitylation makes its mark on Rap2 and cell motility |
| title_short | Non-canonical ubiquitylation makes its mark on Rap2 and cell motility |
| title_sort | non-canonical ubiquitylation makes its mark on rap2 and cell motility |
| topic | Spotlight |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961291/ https://www.ncbi.nlm.nih.gov/pubmed/35333280 http://dx.doi.org/10.1083/jcb.202203029 |
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