Inhibition of Microbiota-dependent Trimethylamine N-Oxide Production Ameliorates High Salt Diet-Induced Sympathetic Excitation and Hypertension in Rats by Attenuating Central Neuroinflammation and Oxidative Stress

Excessive dietary salt intake induces neuroinflammation and oxidative stress in the brain, which lead to sympathetic excitation, contributing to hypertension. However, the underlying mechanisms remain elusive. Accumulating evidence reveals that trimethylamine-N-oxide (TMAO), a gut microbiota-derived...

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Detalles Bibliográficos
Autores principales: Liu, Gang, Cheng, Jiayin, Zhang, Tianhao, Shao, Yingxin, Chen, Xiangxu, Han, Lihong, Zhou, Ru, Wu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961329/
https://www.ncbi.nlm.nih.gov/pubmed/35359866
http://dx.doi.org/10.3389/fphar.2022.856914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961329/
https://www.ncbi.nlm.nih.gov/pubmed/35359866
http://dx.doi.org/10.3389/fphar.2022.856914

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