Orchestration of energy metabolism and osteogenesis by Mg(2+) facilitates low-dose BMP-2-driven regeneration

The clinical application of bone morphogenetic protein-2 (BMP-2) is limited by several factors, including ineffectiveness at low doses and severe adverse effects at high doses. To address these efficacy and safety limitations, we explored whether orchestration of energy metabolism and osteogenesis b...

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Detalles Bibliográficos
Autores principales: Lin, Sihan, Yin, Shi, Shi, Junfeng, Yang, Guangzheng, Wen, Xutao, Zhang, Wenjie, Zhou, Mingliang, Jiang, Xinquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961427/
https://www.ncbi.nlm.nih.gov/pubmed/35387176
http://dx.doi.org/10.1016/j.bioactmat.2022.03.024