Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA, adenoviral vector and inactivated vaccines fail to induce. Here, we describe a candidate live attenuated vaccine strain of SARS-CoV-2 in which the NSP16 gene, which encodes 2′-O-methyltr...

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Detalles Bibliográficos
Autores principales: Ye, Zi-Wei, Ong, Chon Phin, Tang, Kaiming, Fan, Yilan, Luo, Cuiting, Zhou, Runhong, Luo, Peng, Cheng, Yun, Gray, Victor Sebastien, Wang, Pui, Chu, Hin, Chan, Jasper Fuk-Woo, To, Kelvin Kai-Wang, Chen, Honglin, Chen, Zhiwei, Yuen, Kwok-Yung, Ling, Guang Sheng, Yuan, Shuofeng, Jin, Dong-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961489/
https://www.ncbi.nlm.nih.gov/pubmed/35352010
http://dx.doi.org/10.1038/s41423-022-00855-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961489/
https://www.ncbi.nlm.nih.gov/pubmed/35352010
http://dx.doi.org/10.1038/s41423-022-00855-4

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