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Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in Atp8b1 Mutant Mouse Model of Pulmonary Fibrosis

Abnormalities in airway epithelia and lung parenchyma are found in Atp8b1 mutant mice, which develop pulmonary fibrosis after hyperoxic insult. Microarray and ingenuity pathway analysis (IPA) show numerous transcripts involved in ciliogenesis are downregulated in 14-month (14 M) -old Atp8b1 mouse lu...

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Detalles Bibliográficos
Autores principales: Westermann-Clark, Emma, Soundararajan, Ramani, Fukumoto, Jutaro, Patil, Sahebgowda Sidramagowda, Stearns, Timothy M., Saji, Smita, Czachor, Alexander, Hernandez-Cuervo, Helena, Breitzig, Mason, Krishnamurthy, Sudarshan, Lockey, Richard F., Kolliputi, Narasaiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961514/
https://www.ncbi.nlm.nih.gov/pubmed/35204783
http://dx.doi.org/10.3390/biom12020283