Synthesis and Structure–Activity Relationships of Novel Non-Steroidal CYP17A1 Inhibitors as Potential Prostate Cancer Agents

Twenty new compounds, targeting CYP17A1, were synthesized, based on our previous work on a benzimidazole scaffold, and their biological activity evaluated. Inhibition of CYP17A1 is an important modality in the treatment of prostate cancer, which remains the most abundant cancer type in men. The biol...

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Detalles Bibliográficos
Autores principales: Wróbel, Tomasz M., Rogova, Oksana, Sharma, Katyayani, Rojas Velazquez, Maria Natalia, Pandey, Amit V., Jørgensen, Flemming Steen, Arendrup, Frederic S., Andersen, Kasper L., Björkling, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961587/
https://www.ncbi.nlm.nih.gov/pubmed/35204665
http://dx.doi.org/10.3390/biom12020165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961587/
https://www.ncbi.nlm.nih.gov/pubmed/35204665
http://dx.doi.org/10.3390/biom12020165

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