Cargando…

Synthesis and Structure–Activity Relationships of Novel Non-Steroidal CYP17A1 Inhibitors as Potential Prostate Cancer Agents

Twenty new compounds, targeting CYP17A1, were synthesized, based on our previous work on a benzimidazole scaffold, and their biological activity evaluated. Inhibition of CYP17A1 is an important modality in the treatment of prostate cancer, which remains the most abundant cancer type in men. The biol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wróbel, Tomasz M., Rogova, Oksana, Sharma, Katyayani, Rojas Velazquez, Maria Natalia, Pandey, Amit V., Jørgensen, Flemming Steen, Arendrup, Frederic S., Andersen, Kasper L., Björkling, Fredrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961587/ https://www.ncbi.nlm.nih.gov/pubmed/35204665 http://dx.doi.org/10.3390/biom12020165

Ejemplares similares

Non-steroidal CYP17A1 Inhibitors: Discovery and Assessment
por: Wróbel, Tomasz M., et al.
Publicado: (2023)

Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents
por: Wróbel, Tomasz M., et al.
Publicado: (2020)

Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis
por: Wróbel, Tomasz M., et al.
Publicado: (2023)

Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors
por: Bonomo, Silvia, et al.
Publicado: (2016)

No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer.
por: Dunning, A. M., et al.
Publicado: (1998)

Low-Dose Sodium Salicylate Promotes Ovulation by Regulating Steroids via CYP17A1
por: Li, Tao, et al.
Publicado: (2023)

A novel CYP17A1 deletion causes a functional knockout of the steroid enzyme 17-hydroxylase and 17,20-lyase in a Turkish family and illustrates the precise role of the CYP17A1 gene
por: Camats, Núria, et al.
Publicado: (2015)

Influence of CYP2C19*2/*17 genotype on adverse drug reactions of voriconazole in patients after allo-HSCT: a four-case report
por: Beata, Sienkiewicz, et al.
Publicado: (2017)

Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139
por: Shehata, Mohamed A., et al.
Publicado: (2016)

Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity
por: Frederiksen, Nicki, et al.
Publicado: (2019)

Implementation of Isavuconazole in a Fluorescence-Based High-Performance Liquid Chromatography Kit Allowing Simultaneous Detection of All Four Currently Licensed Mold-Active Triazoles
por: Jørgensen, René, et al.
Publicado: (2017)

Identification and Analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1 and CYP51A1 in Cynomolgus Macaques
por: UNO, Yasuhiro, et al.
Publicado: (2014)

Ibrutinib does not have clinically relevant interactions with oral contraceptives or substrates of CYP3A and CYP2B6
por: de Jong, Jan, et al.
Publicado: (2020)

A family based study on T-C transition polymorphism in Cyp17a1 gene in Indian children
por: Gayan, Sukanya, et al.
Publicado: (2014)

In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR(120)) in Aspergillus fumigatus cyp51A, Denmark
por: Hare, Rasmus K., et al.
Publicado: (2019)

PMON52 Use of PDE5 Inhibitors as Potential Treatment for Isolated Growth Hormone Deficiency Caused by Alternate Splicing of GH1 Gene
por: Pandey, Amit V, et al.
Publicado: (2022)

Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency
por: Fernández-Cancio, Mónica, et al.
Publicado: (2018)

Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk
por: Rizzolo, Piera, et al.
Publicado: (2019)

New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies
por: Khalil, Nadia A., et al.
Publicado: (2021)

Two cases of 17α-hydroxylase/17,20-lyase deficiency caused by the CYP17A1 mutation
por: Lee, Hae In, et al.
Publicado: (2021)

Steroid conversion with CYP106A2 – production of pharmaceutically interesting DHEA metabolites
por: Schmitz, Daniela, et al.
Publicado: (2014)

Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk
por: Bethke, Lara, et al.
Publicado: (2007)

Aldehyde Oxidase: Reaction Mechanism and Prediction of Site of Metabolism
por: Montefiori, Marco, et al.
Publicado: (2017)

CYP17A1 Intron Mutation Causing Cryptic Splicing in 17α-Hydroxylase Deficiency
por: Hwang, Daw-Yang, et al.
Publicado: (2011)

A polymorphism in the CYP17 gene is associated with male breast cancer
por: Young, I E, et al.
Publicado: (1999)

CYP17 and breast cancer: no overall effect, but what about interactions?
por: Little, Julian, et al.
Publicado: (2005)

Does a polymorphism in the CYP17 gene predict mammographic density?
por: Ursin, G, et al.
Publicado: (2000)

CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence
por: Van Woudenberg, Mariel, et al.
Publicado: (2015)

Common variation of the CYP17 gene in Iraqi women with endometriosis disease
por: Al-Rubae'i, Salwa H.N., et al.
Publicado: (2016)

Enzymatic Characterization and Comparison of Two Steroid Hydroxylases CYP154C3-1 and CYP154C3-2 from Streptomyces Species
por: Subedi, Pradeep, et al.
Publicado: (2021)

Selective steroid oxyfunctionalisation by CYP154C5, a bacterial cytochrome P450
por: Bracco, Paula, et al.
Publicado: (2013)

Development and validation of a method for the simultaneous quantification of endogenous steroids metabolized by CYP3A
por: Lee, Yujin, et al.
Publicado: (2020)

CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering
por: Bracco, Paula, et al.
Publicado: (2020)

The CYP2C19*2 and CYP2C19*17 Polymorphisms Influence Responses to Clozapine for the Treatment of Schizophrenia
por: Rodrigues-Silva, Christielly, et al.
Publicado: (2020)

Loss of Protein Stability and Function Caused by P228L Variation in NADPH-Cytochrome P450 Reductase Linked to Lower Testosterone Levels
por: Rojas Velazquez, Maria Natalia, et al.
Publicado: (2022)

A Novel Compound Heterozygous CYP17A1 Variant Causes 17α-Hydroxylase/17, 20-Lyase Deficiency
por: Chen, Hong, et al.
Publicado: (2019)

The broad phenotypic spectrum of 17α-hydroxylase/17,20-lyase (CYP17A1) deficiency: a case series
por: Sun, Min, et al.
Publicado: (2021)

Altered CYP19A1 and CYP3A4 Activities Due to Mutations A115V, T142A, Q153R and P284L in the Human P450 Oxidoreductase
por: Udhane, Sameer S., et al.
Publicado: (2017)

Prevalence of CYP17A1 gene mutations in 17α-hydroxylase deficiency in the Chinese Han population
por: Wang, Menglin, et al.
Publicado: (2019)

Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans
por: Ghisari, Mandana, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_v8nd1aetrr82jkg6ccpgg773ke