APR-246—The Mutant TP53 Reactivator—Increases the Effectiveness of Berberine and Modified Berberines to Inhibit the Proliferation of Pancreatic Cancer Cells

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. In ~75% of PDAC, the tumor suppressor TP53 gene is mutated. Novel approaches to treat cancer involve compounds called mutant TP53 reactivators. They interact with mutant TP53 proteins and restore some of their grow...

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Detalles Bibliográficos
Autores principales: McCubrey, James Andrew, Abrams, Stephen L., Steelman, Linda S., Cocco, Lucio, Ratti, Stefano, Martelli, Alberto M., Lombardi, Paolo, Gizak, Agnieszka, Duda, Przemysław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961609/
https://www.ncbi.nlm.nih.gov/pubmed/35204775
http://dx.doi.org/10.3390/biom12020276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961609/
https://www.ncbi.nlm.nih.gov/pubmed/35204775
http://dx.doi.org/10.3390/biom12020276

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