Cargando…
Human β-Defensin 2 (HBD-2) Displays Oncolytic Activity but Does Not Affect Tumour Cell Migration
Defensins form an integral part of the cationic host defence peptide (HDP) family, a key component of innate immunity. Apart from their antimicrobial and immunomodulatory activities, many HDPs exert multifaceted effects on tumour cells, notably direct oncolysis and/or inhibition of tumour cell migra...
Autores principales: | Bindra, Guneet K., Williams, Scott A., Lay, Fung T., Baxter, Amy A., Poon, Ivan K. H., Hulett, Mark D., Phan, Thanh Kha |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961614/ https://www.ncbi.nlm.nih.gov/pubmed/35204765 http://dx.doi.org/10.3390/biom12020264 |
Ejemplares similares
-
Human β-defensin 3 contains an oncolytic motif that binds PI(4,5)P(2) to mediate tumour cell permeabilisation
por: Phan, Thanh Kha, et al.
Publicado: (2015) -
Crocodile defensin (CpoBD13) antifungal activity via pH-dependent phospholipid targeting and membrane disruption
por: Williams, Scott A., et al.
Publicado: (2023) -
Human β-defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate–mediated membrane permeabilization
por: Järvå, Michael, et al.
Publicado: (2018) -
Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics
por: Hein, Matthew J. A., et al.
Publicado: (2022) -
X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex
por: Järvå, Michael, et al.
Publicado: (2018)