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Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices

The accumulation of α-synuclein (α-syn) in the brain plays a role in synucleinopathies and it is hypothesized to spread in a prion-like fashion between connected brain regions. In the present study, we aim to investigate this spreading in well-characterized sagittal organotypic whole brain slices ta...

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Detalles Bibliográficos
Autores principales: Uçar, Buket, Stefanova, Nadia, Humpel, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961638/
https://www.ncbi.nlm.nih.gov/pubmed/35204664
http://dx.doi.org/10.3390/biom12020163