Preparative Production of Functionalized (N- and O-Heterocyclic) Polycyclic Aromatic Hydrocarbons by Human Cytochrome P450 3A4 in a Bioreactor

Polycyclic aromatic hydrocarbons (PAHs) and their N- and O-containing derivatives (N-/O-PAHs) are environmental pollutants and synthetically attractive building blocks in pharmaceuticals. Functionalization of PAHs can be achieved via C-H activation by cytochrome P450 enzymes (e.g., P450 CYP3A4) in a...

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Detalles Bibliográficos
Autores principales: Srdič, Matic, Fessner, Nico D., Yildiz, Deniz, Glieder, Anton, Spiertz, Markus, Schwaneberg, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961652/
https://www.ncbi.nlm.nih.gov/pubmed/35204652
http://dx.doi.org/10.3390/biom12020153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961652/
https://www.ncbi.nlm.nih.gov/pubmed/35204652
http://dx.doi.org/10.3390/biom12020153

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