6-Hydroxydopamine Induces Abnormal Iron Sequestration in BV2 Microglia by Activating Iron Regulatory Protein 1 and Inhibiting Hepcidin Release

Disrupted iron homeostasis in the substantia nigra pars compacta (SNpc) is an important pathological mechanism in Parkinson’s disease (PD). It is unclear what role microglia play in iron metabolism and selective iron deposition in the SNpc of PD brain. In this study, we observed that 6-hydroxydopami...

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Detalles Bibliográficos
Autores principales: Xu, Manman, Li, Yinghui, Meng, Dapeng, Zhang, Danyang, Wang, Bingjing, Xie, Junxia, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961664/
https://www.ncbi.nlm.nih.gov/pubmed/35204767
http://dx.doi.org/10.3390/biom12020266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961664/
https://www.ncbi.nlm.nih.gov/pubmed/35204767
http://dx.doi.org/10.3390/biom12020266

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