Single Application of Low-Dose, Hydroxyapatite-Bound BMP-2 or GDF-5 Induces Long-Term Bone Formation and Biomechanical Stabilization of a Bone Defect in a Senile Sheep Lumbar Osteopenia Model

Effects of hydroxyapatite (HA) particles with bone morphogenetic BMP-2 or GDF-5 were compared in sheep lumbar osteopenia; in vitro release in phosphate-buffered saline (PBS) or sheep serum was assessed by ELISA. Lumbar (L) vertebral bone defects (Ø 3.5 mm) were generated in aged, osteopenic female s...

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Detalles Bibliográficos
Autores principales: Hasenbein, Ines, Sachse, André, Hortschansky, Peter, Schmuck, Klaus D., Horbert, Victoria, Anders, Christoph, Lehmann, Thomas, Huber, René, Maslaris, Alexander, Layher, Frank, Braun, Christina, Roth, Andreas, Plöger, Frank, Kinne, Raimund W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962316/
https://www.ncbi.nlm.nih.gov/pubmed/35203721
http://dx.doi.org/10.3390/biomedicines10020513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962316/
https://www.ncbi.nlm.nih.gov/pubmed/35203721
http://dx.doi.org/10.3390/biomedicines10020513

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