Single Application of Low-Dose, Hydroxyapatite-Bound BMP-2 or GDF-5 Induces Long-Term Bone Formation and Biomechanical Stabilization of a Bone Defect in a Senile Sheep Lumbar Osteopenia Model

Effects of hydroxyapatite (HA) particles with bone morphogenetic BMP-2 or GDF-5 were compared in sheep lumbar osteopenia; in vitro release in phosphate-buffered saline (PBS) or sheep serum was assessed by ELISA. Lumbar (L) vertebral bone defects (Ø 3.5 mm) were generated in aged, osteopenic female s...

Descripción completa

Detalles Bibliográficos
Autores principales: Hasenbein, Ines, Sachse, André, Hortschansky, Peter, Schmuck, Klaus D., Horbert, Victoria, Anders, Christoph, Lehmann, Thomas, Huber, René, Maslaris, Alexander, Layher, Frank, Braun, Christina, Roth, Andreas, Plöger, Frank, Kinne, Raimund W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962316/
https://www.ncbi.nlm.nih.gov/pubmed/35203721
http://dx.doi.org/10.3390/biomedicines10020513

Ejemplares similares

Ejemplares similares