Cytoprotective Effect of Idebenone through Modulation of the Intrinsic Mitochondrial Pathway of Apoptosis in Human Retinal Pigment Epithelial Cells Exposed to Oxidative Stress Induced by Hydrogen Peroxide

Idebenone is a ubiquinone short-chain synthetic analog with antioxidant properties, which is believed to restore mitochondrial ATP synthesis. As such, idebenone is investigated in numerous clinical trials for diseases of mitochondrial aetiology and it is authorized as a drug for the treatment of Leb...

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Detalles Bibliográficos
Autores principales: Clementi, Maria Elisabetta, Pizzoferrato, Michela, Bianchetti, Giada, Brancato, Anna, Sampaolese, Beatrice, Maulucci, Giuseppe, Tringali, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962354/
https://www.ncbi.nlm.nih.gov/pubmed/35203712
http://dx.doi.org/10.3390/biomedicines10020503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962354/
https://www.ncbi.nlm.nih.gov/pubmed/35203712
http://dx.doi.org/10.3390/biomedicines10020503

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