Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders

BACKGROUND: Deoxythymidine triphosphate (dTTP) is an essential building block of DNA, and defects in enzymes involved in dTTP synthesis cause neurodegenerative disorders. For instance, mutations in DTYMK, the gene coding for thymidylate kinase (TMPK), cause severe microcephaly in human. However, the...

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Detalles Bibliográficos
Autores principales: Frisk, Junmei Hu, Örn, Stefan, Pejler, Gunnar, Eriksson, Staffan, Wang, Liya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962455/
https://www.ncbi.nlm.nih.gov/pubmed/35346037
http://dx.doi.org/10.1186/s12868-022-00704-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962455/
https://www.ncbi.nlm.nih.gov/pubmed/35346037
http://dx.doi.org/10.1186/s12868-022-00704-0

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