Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development

Neuron-glia interactions play a critical role in the regulation of synapse formation and circuit assembly. Here we demonstrate that canonical Sonic hedgehog (Shh) pathway signaling in cortical astrocytes acts to coordinate layer-specific synaptic connectivity. We show that the Shh receptor Ptch1 is...

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Detalles Bibliográficos
Autores principales: Xie, Yajun, Kuan, Aaron T., Wang, Wengang, Herbert, Zachary T., Mosto, Olivia, Olukoya, Olubusola, Adam, Manal, Vu, Steve, Kim, Minsu, Tran, Diana, Gómez, Nicolás, Charpentier, Claire, Sorour, Ingie, Lacey, Tiara E., Tolstorukov, Michael Y., Sabatini, Bernardo L., Lee, Wei-Chung Allen, Harwell, Corey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962654/
https://www.ncbi.nlm.nih.gov/pubmed/35196485
http://dx.doi.org/10.1016/j.celrep.2022.110416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962654/
https://www.ncbi.nlm.nih.gov/pubmed/35196485
http://dx.doi.org/10.1016/j.celrep.2022.110416

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