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Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations

We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular adaptations. Trained men (n = 15, age: 23 ± 3 years; training experience: 7 ± 3 years) performed unilateral lower-body training...

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Autores principales: Vann, Christopher G., Sexton, Casey L., Osburn, Shelby C., Smith, Morgan A., Haun, Cody T., Rumbley, Melissa N., Mumford, Petey W., Montgomery, Nathan T., Ruple, Bradley A., McKendry, James, Mcleod, Jonathan, Bashir, Adil, Beyers, Ronald J., Brook, Matthew S., Smith, Kenneth, Atherton, Philip J., Beck, Darren T., McDonald, James R., Young, Kaelin C., Phillips, Stuart M., Roberts, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962955/
https://www.ncbi.nlm.nih.gov/pubmed/35360253
http://dx.doi.org/10.3389/fphys.2022.857555
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author Vann, Christopher G.
Sexton, Casey L.
Osburn, Shelby C.
Smith, Morgan A.
Haun, Cody T.
Rumbley, Melissa N.
Mumford, Petey W.
Montgomery, Nathan T.
Ruple, Bradley A.
McKendry, James
Mcleod, Jonathan
Bashir, Adil
Beyers, Ronald J.
Brook, Matthew S.
Smith, Kenneth
Atherton, Philip J.
Beck, Darren T.
McDonald, James R.
Young, Kaelin C.
Phillips, Stuart M.
Roberts, Michael D.
author_facet Vann, Christopher G.
Sexton, Casey L.
Osburn, Shelby C.
Smith, Morgan A.
Haun, Cody T.
Rumbley, Melissa N.
Mumford, Petey W.
Montgomery, Nathan T.
Ruple, Bradley A.
McKendry, James
Mcleod, Jonathan
Bashir, Adil
Beyers, Ronald J.
Brook, Matthew S.
Smith, Kenneth
Atherton, Philip J.
Beck, Darren T.
McDonald, James R.
Young, Kaelin C.
Phillips, Stuart M.
Roberts, Michael D.
author_sort Vann, Christopher G.
collection PubMed
description We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular adaptations. Trained men (n = 15, age: 23 ± 3 years; training experience: 7 ± 3 years) performed unilateral lower-body training for 6 weeks (3× weekly), where single legs were randomly assigned to HV and HL paradigms. Vastus lateralis (VL) biopsies were obtained prior to study initiation (PRE) as well as 3 days (POST) and 10 days following the last training bout (POSTPR). Body composition and strength tests were performed at each testing session, and biochemical assays were performed on muscle tissue after study completion. Two-way within-subject repeated measures ANOVAs were performed on most dependent variables, and tracer data were compared using dependent samples t-tests. A significant interaction existed for VL muscle cross-sectional area (assessed via magnetic resonance imaging; interaction p = 0.046), where HV increased this metric from PRE to POST (+3.2%, p = 0.018) whereas HL training did not (−0.1%, p = 0.475). Additionally, HL increased leg extensor strength more so than HV training (interaction p = 0.032; HV < HL at POST and POSTPR, p < 0.025 for each). Six-week integrated non-myofibrillar protein synthesis (iNon-MyoPS) rates were also higher in the HV versus HL condition, while no difference between conditions existed for iMyoPS rates. No interactions existed for other strength, VL morphology variables, or the relative abundances of major muscle proteins. Compared to HL training, 6 weeks of HV training in previously trained men optimizes VL hypertrophy in lieu of enhanced iNon-MyoPS rates, and this warrants future research.
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spelling pubmed-89629552022-03-30 Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations Vann, Christopher G. Sexton, Casey L. Osburn, Shelby C. Smith, Morgan A. Haun, Cody T. Rumbley, Melissa N. Mumford, Petey W. Montgomery, Nathan T. Ruple, Bradley A. McKendry, James Mcleod, Jonathan Bashir, Adil Beyers, Ronald J. Brook, Matthew S. Smith, Kenneth Atherton, Philip J. Beck, Darren T. McDonald, James R. Young, Kaelin C. Phillips, Stuart M. Roberts, Michael D. Front Physiol Physiology We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular adaptations. Trained men (n = 15, age: 23 ± 3 years; training experience: 7 ± 3 years) performed unilateral lower-body training for 6 weeks (3× weekly), where single legs were randomly assigned to HV and HL paradigms. Vastus lateralis (VL) biopsies were obtained prior to study initiation (PRE) as well as 3 days (POST) and 10 days following the last training bout (POSTPR). Body composition and strength tests were performed at each testing session, and biochemical assays were performed on muscle tissue after study completion. Two-way within-subject repeated measures ANOVAs were performed on most dependent variables, and tracer data were compared using dependent samples t-tests. A significant interaction existed for VL muscle cross-sectional area (assessed via magnetic resonance imaging; interaction p = 0.046), where HV increased this metric from PRE to POST (+3.2%, p = 0.018) whereas HL training did not (−0.1%, p = 0.475). Additionally, HL increased leg extensor strength more so than HV training (interaction p = 0.032; HV < HL at POST and POSTPR, p < 0.025 for each). Six-week integrated non-myofibrillar protein synthesis (iNon-MyoPS) rates were also higher in the HV versus HL condition, while no difference between conditions existed for iMyoPS rates. No interactions existed for other strength, VL morphology variables, or the relative abundances of major muscle proteins. Compared to HL training, 6 weeks of HV training in previously trained men optimizes VL hypertrophy in lieu of enhanced iNon-MyoPS rates, and this warrants future research. Frontiers Media S.A. 2022-03-11 /pmc/articles/PMC8962955/ /pubmed/35360253 http://dx.doi.org/10.3389/fphys.2022.857555 Text en Copyright © 2022 Vann, Sexton, Osburn, Smith, Haun, Rumbley, Mumford, Montgomery, Ruple, McKendry, Mcleod, Bashir, Beyers, Brook, Smith, Atherton, Beck, McDonald, Young, Phillips and Roberts. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Vann, Christopher G.
Sexton, Casey L.
Osburn, Shelby C.
Smith, Morgan A.
Haun, Cody T.
Rumbley, Melissa N.
Mumford, Petey W.
Montgomery, Nathan T.
Ruple, Bradley A.
McKendry, James
Mcleod, Jonathan
Bashir, Adil
Beyers, Ronald J.
Brook, Matthew S.
Smith, Kenneth
Atherton, Philip J.
Beck, Darren T.
McDonald, James R.
Young, Kaelin C.
Phillips, Stuart M.
Roberts, Michael D.
Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations
title Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations
title_full Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations
title_fullStr Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations
title_full_unstemmed Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations
title_short Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations
title_sort effects of high-volume versus high-load resistance training on skeletal muscle growth and molecular adaptations
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962955/
https://www.ncbi.nlm.nih.gov/pubmed/35360253
http://dx.doi.org/10.3389/fphys.2022.857555
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