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Current structure predictors are not learning the physics of protein folding

SUMMARY: Motivation. Predicting the native state of a protein has long been considered a gateway problem for understanding protein folding. Recent advances in structural modeling driven by deep learning have achieved unprecedented success at predicting a protein’s crystal structure, but it is not cl...

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Detalles Bibliográficos
Autores principales: Outeiral, Carlos, Nissley, Daniel A, Deane, Charlotte M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963306/
https://www.ncbi.nlm.nih.gov/pubmed/35099504
http://dx.doi.org/10.1093/bioinformatics/btab881