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SCONCE: a method for profiling copy number alterations in cancer evolution using single-cell whole genome sequencing
MOTIVATION: Copy number alterations (CNAs) are a significant driver in cancer growth and development, but remain poorly characterized on the single cell level. Although genome evolution in cancer cells is Markovian through evolutionary time, CNAs are not Markovian along the genome. However, existing...
Autores principales: | Hui, Sandra, Nielsen, Rasmus |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963318/ https://www.ncbi.nlm.nih.gov/pubmed/35080614 http://dx.doi.org/10.1093/bioinformatics/btac041 |
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